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grief

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Grief describes a feeling of great sadness, especially when caused by a loss or death, or grief can describe being the cause of trouble for someone. (noun)

An example of grief is what you feel after your spouse dies.
An example of grief is when you constantly tease your friend about his new haircut.

See grief in Webster's New World College Dictionary

noun

intense emotional suffering caused by loss, disaster, misfortune, etc.; acute sorrow; deep sadness
a cause or the subject of such suffering
Informal
1. irritation or frustration, esp. from accidents, mishaps, etc.: the griefs of a computer operator
2. trouble; difficulty; problem: enough grief for one day
3. a cause of any of these

See grief in American Heritage Dictionary 4

(grēf)

noun

Deep mental anguish, as that arising from bereavement. See Synonyms at regret.
A source of deep mental anguish.
Annoyance or frustration: Trying to follow their directions was nothing but grief.
Trouble or difficulty: the griefs of trying to meet a deadline.
Archaic A grievance.

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