During the rule of the nobles and the mixed rule of nobles and popolani the commune of Siena was enlarged by fortunate acquisitions of neighbouring lands and by the submission of feudal lords, such as the Scialenghi, Aldobrandeschi, Pannocchieschi, Visconti di Campiglia, &c.
His Silesian and Austrian acquisitions were also very beneficial to trade, throwing open as they did the western markets to Hungarian produce.
In one speech, referring to Cyprus and the Transvaal, he said: " If those acquisitions were as valuable as they are valueless, I would repudiate them, because they were obtained by means dishonourable to the character of our country."
His object was to make all the anatomical and physiological acquisitions of his age, even microscopical anatomy, which he diligently studied, available for use in the practice of medicine.
Under his administration the library was enriched with numerous gifts, legacies and acquisitions, notably by the purchase of a part of the Ashburnham MSS.