Sickle-cell-anaemia meaning

(UK) A disease characterized by sickle-shaped red blood cells.
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(pathology, UK) A severe hereditary form of anaemia, mainly affecting people of African origin, in which mutated haemoglobin distorts red blood cells into a crescent shape, causing the cells to become stuck in capillaries. Downstream tissues are thus deprived of oxygen causing ischaemia and infarction.
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