An example of a disease is cancer.
Mote he soft himselfe appease, / And fairely fare on foot, how euer loth; / His double burden did him sore disease.
Origin of disease
- Middle English disese from Old French des- dis- aise ease ease
From American Heritage Dictionary of the English Language, 5th Edition
- Middle English disese, from Anglo-Norman desese, disaise, from Old French desaise (dis- + ease). Displaced native Middle English adle, audle (“disease”) (from Old English ādl (“disease, sickness”)), Middle English cothe, coathe (“disease”) (from Old English coþu (“disease”)).