When the family road trip is delayed a few days due to car trouble, it is an example of something going amiss.
An example of something amiss is when a school of fish are supposed to swim to a certain spot each year to reproduce, but a change in water temperatures prevents it from happening.
When a computer isn’t working properly and it configures incorrect data, it is an example of something that is amiss.
An example of amiss in the negative is when a teacher is late for class and she rushes in expecting mass chaos, but instead all the students are working hard and nothing is wrong.
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See amiss in Webster's New World College Dictionary
See amiss in American Heritage Dictionary 4
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