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An example of a despicable person was Jack the Ripper.
Yes, what she did early on was despicable in our minds, but put yourself in her position.
My father did it because, to him, lying was so despicable he was forced to respond in a like manner.
Her despicable behavior earned her nothing but some time in jail.
Though I so love him and trust his every word, I can't help but tremble at even the prospect I shall at last exchange this soiled and despicable life for another.
This did not appear the worst, nor by any means a despicable alternative.