It has not indeed proved practically available; but his system of calculating cometary perturbations by means of "mechanical quadratures" has formed the startingpoint of all subsequent researches on the subject.
The discordance of their results incited Laplace to a searching examination of the whole subject of planetary perturbations, and his maiden effort was rewarded with a discovery which constituted, when developed and completely demonstrated by his own further labours and those of his illustrious rival Lagrange, the most important advance made in physical astronomy since the time of Newton.
Many of the symptoms of diseases were caused by the passions and perturbations of the archeus, and medicines acted by modifying the ideas of the same archeus.
Thus it came about not only that classifications of disease based on superficial likeness - such as jaundice, dropsy, inflammation - were broken up, and their parts redistributed, but also that even more set diseases began to lose their settlements, and were recognized as terms of series, as transitory or culminating phases of perturbations which might be traced to their origins, and in their earlier stages perhaps withstood.
This law has important ethical and political bearings; but in the province of disease this advance of what may be compared to the interlocking of points and signals has had wide influence not only in altering our conceptions of disease, but also in enlarging our views of all perturbations of function.