Cloned pigs, sheep and cows have malfunctioning immune systems.
caprice of nature; a broken projector at the local movie palace; a malfunctioning condom?
The question you must ask is - are you prepared to suffer the consequences of your system failing or malfunctioning?
malfunctioning equipment should be repaired on-site or close to the site.
malfunctioning cells in the body, without cutting into it - that's the holy grail of surgery.