mutation
mutation
Definition
mu·ta·tion (myo̵̅o̅ tā′s̸hən)
noun
- a changing or being changed
- a change, as in form, nature, qualities, etc.
- Biol.
- a sudden variation in some inheritable characteristic in a germ cell of an individual animal or plant, as distinguished from a variation resulting from generations of gradual change
- an individual resulting from such variation; mutant
- an abrupt and relatively permanent change in somatic cells that is transmitted only to daughter cells and can be inherited only in plants that reproduce asexually
- Linguis.
- umlaut (sense )
- alternation of consonants under specific conditions, as in variations in the initial consonant of a word in Irish and other Celtic languages
Etymology: ME mutacioun < OFr mutacion < L mutatio < mutare, to change: see miss
mu·ta′·tional adjective
mu·ta′·tion·ally adverb
mutation
Synonyms
mutation
Usage Examples
Converse of object
- inherit: Not everyone who has inherited a genetic mutation for Gaucher disease from both parents has symptoms.
- attenuating: The attenuating mutation at residue 91 in VP3 is shown in cyan, and all suppressor mutations are shown in white.
- truncate: Milder disease was observed in some cases carrying missense mutations as compared with those carrying truncating mutations.
- induce: More recently, I have been involved in the detailed determination of gene function through induced mutation of the genes encoding renin.
Preposition: in
- exon: No point mutation in exons 20 to 24 and their flanking introns were found in any of the 35 patients.
- gene: A mutation in a patterning gene could give rise to a simple heart defect, not a full scale patterning defect.
Adjective modifier
- somatic: These genes are often screened for somatic mutations only in the region most likely to contain mutations.
- brca2: Comment: The clinical relevance of this paper is unclear, as no-one is currently proposing population screening for BRCA1 and BRCA2 mutations.
- genetic: However a gap remained between linking a genetic mutation to the outcome of the disease.
- brca1: That is, women with negative results for BRCA1 mutation are still at risk of cancer.
- missense: This project addresses how missense mutations are analyzed before an interpreted report is issued.
- deleterious: High frequency of cryptic deleterious mutations in Caenorhabditis elegans.
Modifies a noun
- assay: Negative results are available for a gene mutation assay in Salmonella.
- carrier: Should cancers in mutation carriers be managed differently from sporadic cases?
Noun used with modifier
- missense: Missense mutation analysis This project is investigating the application of bioinformatic tools to determine the pathogenicity of unclassified missense mutations.
- p53: The survival rate in the 24 patients with p53 mutation did not differ significantly from that in the 16 patients without p53 mutation.
- germline: Many members of Li-Fraumeni families have a germline mutation of the TP53 gene.
- frameshift: It was not able to induce point and frameshift mutations in haploid Saccharomyces cerevisiae cells.
- gene: Importantly, in rare families, a gene mutation has been shown to cause the abnormal build up of tau protein in the brain.
- mtdna: By contrast, a woman with a heteroplasmic mtDNA mutation, may transmit a variable amount of mutated mtDNA to her children.
