In toxic doses podophyllin causes intense enteritis, with all its characteristic symptoms, and severe depression, which may end in death.
The now well-known fact that small doses of poisonous substances may act as stimuli to living protoplasm, and that respiratory activity and growth may be accelerated by chloroform, ether and even powerful mineral poisons, such as mercuric chloride, in minimal doses, offers some explanation of these phenomena of hypertrophy, wound fever, and other responses to the presence of irritating agents.
Taken internally, in doses of from one to three grains, carbolic acid will often relieve obstinate cases of vomiting and has some value as a gastric antiseptic.
Colchicine is the active principle and may be given in full form in doses of to 1 1 8 grain.
The British Pharmacopoeia contains (i) an extract of the fresh corm, having doses of 4 to i grain, and (2) the Vinum Colchici, made by treating the dried corm with sherry and given in doses of 10 to 30 minims. This latter is the preparation still most generally used, though the presence of veratrine both in the corm and the seeds renders the use of colchicine itself theoretically preferable.
How would you define doses? Add your definition here.