According to Ross, it should be given promptly, in sufficient doses (up to 30 grains), and should be continued for months.
Given by the mouth glycerin produces purging if large doses are administered, and has the same action if only a small quantity be introduced into the rectum.
Very large doses in animals cause lethargy, collapse and death.
In toxic doses podophyllin causes intense enteritis, with all its characteristic symptoms, and severe depression, which may end in death.
The now well-known fact that small doses of poisonous substances may act as stimuli to living protoplasm, and that respiratory activity and growth may be accelerated by chloroform, ether and even powerful mineral poisons, such as mercuric chloride, in minimal doses, offers some explanation of these phenomena of hypertrophy, wound fever, and other responses to the presence of irritating agents.