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tachyphylaxis

(tăkˌə-fĭ-lăkˈsĭs)

noun pl. tach·y·phy·lax·es (-fĭ-lăkˈsēz)
  1. Rapid desensitization to a toxic substance produced by inoculation with a series of small doses.
  2. A rapidly decreasing response to a drug following administration of the initial doses.

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