In opposition to something.
Idioms, Phrasal Verbs Related to Against
Origin of Against
Formed from Middle English agenes, againes (“in opposition to”), a southern variant of agen, or directly from again, either way with adverbial genitive singular ending -es; the parasitic -t was added circa 1350, probably by confusion with the superlative ending -est. Surface analysis again + -st (“(excrescence)”).
Middle English alteration of againes from Old English ongeagn
From American Heritage Dictionary of the English Language, 5th Edition
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