Agen changed hands more than once in the course of the Albigensian wars, and at their close a tribunal of inquisition was established in the town and inflicted cruel persecution on the heretics.
During the religious wars of the 16th century Agen took the part of the Catholics and openly joined the League in 1589.
In 1671 he was appointed bishop of Tulle; eight years later he was transferred to the larger diocese of Agen.
During his later years he devoted himself entirely to his pastoral duties at Agen, where he died in 1703.
In ancient Gaul it was the country of the Nitiobroges with Aginnum for its capital, and in the 4th century it was the Civitas Agennensium which was a part of Aquitania Secunda and which formed the diocese of Agen.