Hemoglobinopathies-Abnormal hemoglobins in the blood, i.e., sickle cell disease, thalessemia.
An individual's stage in development determines whether he or she makes primarily embryonic, fetal, or adult hemoglobins.
Hemoglobins migrate through this gel at various rates and to specific locations, depending on their size, shape, and electrical charge.
Isoelectric focusing and high-performance liquid chromatography (HPLC) use similar principles to separate hemoglobins.
Hemoglobin electrophoresis can also detect structurally abnormal hemoglobins that may be co-inherited with a thalassemia trait.