Dean was childless but Cynthia was mother to a twenty-year-old college student.
In 1777 Edward, the ninth of the Howard dukes, died childless in his ninety-second year.
His Irish title descended to his brother William, the general, who died childless in 1814.
All other daughters had only a life interest in their dowry, which reverted to their family, if childless, or went to their children if they had any.
Antonio and Francesco both having died childless, the duchy passed to Charles of Bourbon (Don Carlos), infante of Spain, who, becoming king of Naples in 1734, surrendered Parma and Piacenza to Austria, but retained the artistic treasures of the Farnese dynasty which he had removed from Parma to Naples.