- the tenderest part of a loin of beef, pork, etc., located on either side of the backbone and consisting of the psoas muscle
- [usuallyT-] any urban district similar to the Tenderloin
- The tenderest part of a loin of beef, pork, or similar cut of meat.
- A city district notorious for vice and graft.
Origin of tenderloinSense 2, after the Tenderloin , an area of New York City (from the easy income it once afforded corrupt policemen)