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mediate Definition

me·di·ate (mē′dē āt′; for adj., -it)

intransitive verb -·at′ed, -·at′·ing

  1. to be in an intermediate position or location
  2. to be an intermediary or conciliator between persons or sides

Etymology: < LL mediatus, pp. of mediare, to divide in the middle < L medius, middle: see mid

transitive verb

    1. to settle by mediation mediated the dispute
    2. to bring about by conciliation mediated a settlement
  2. to be the medium for bringing about (a result), conveying (an object), communicating (information), etc.

adjective

  1. Now Rare intermediate or intervening
  2. dependent on, acting by, or connected through some intervening agency; related indirectly

mediate Related Forms

me′·di·ately adverb me′·dia′·tor noun

mediate Synonyms

mediate

v.

arbitrate, propitiate, interfere, intercede; see negotiate 1, reconcile 2.

mediate Usage Examples

Object

  • adhesion: Integrins mediate adhesion of cells to the extracellular matrix as well as to other cells.
  • lysis: In comparisons in complement mediated lysis with CD52 antibodies of different IgG1 allotypes there is very little difference between them.
  • immunity: Impaired cell mediated immunity in hemophilia in the absence of infection with human immunodeficiency virus.
  • endocytosis: For example, most cells take up cholesterol through receptor mediated endocytosis.
  • inhibition: Zonisamide also has a modulatory effect on GABA mediated neuronal inhibition.
  • vasoconstriction: This receptor mediates vasoconstriction ( Hallworth, 1997 ).

Subject

  • cytokines: This response is most probably triggered by the bacterium's lipopolysaccharide, urease, and/or cytotoxins and is mediated by cytokines.
  • inhibition: There is thus the potential of drug interactions mediated by inhibition of transporters.
  • receptor: The extent to which nausea and vomiting are mediated by opioid receptors is arguable.

Modifying Another Word

  • technologically: The proposed research will explore the concept of situated learning in the context and accomplishment of safety in technologically mediated medical work.
  • vagally: The approach used a nasal cold dry air challenge to induce a vagally mediated bronchoconstriction.
  • neurally: Drugwatch Fludrocortisone for low blood pressure / neurally mediated hypotension?
  • electronically: Issues of this kind raise more general ones about the future of scientific discourse in an electronically mediated world.
  • digitally: When we move from face to face interaction to digitally mediated interaction, however, everything changes.
  • culturally: The objection to this viewpoint is that historians have repeatedly shown that medical knowledge and practice are ' constructed ' and are culturally mediated.

Preposition: by

  • cytokines: This response is most probably triggered by the bacterium's lipopolysaccharide, urease, and/or cytotoxins and is mediated by cytokines.
  • inhibition: There is thus the potential of drug interactions mediated by inhibition of transporters.
  • receptor: The extent to which nausea and vomiting are mediated by opioid receptors is arguable.
  • interaction: Cell adherens junctions are points of cell-cell contact, mediated by the extracellular interactions of cadherin molecules.

Preposition: in

dispute: In 1839, the Presbytery were called upon to mediate in further disputes between the minister and the heritors.