She single-handedly organized the whole event, and even set up all the chairs herself.
Because you're single-handedly destroying the universe.
Single-handedly, the most important part of your laptop computer is its processor.
In competing in these events he will become the first person with a disability to single-handedly circumnavigate the Globe non-stop.
Follow Iggy round the globe as he suffers stage fright in front of David Bowie, and single-handedly takes on Pepsi Cola.