Hansemann's "anaplasia " hypothesis seeks to find an explanation of the formation of new growths in the absence of the histological differentiation of the cell associated with a corresponding increase in its proliferative power and a suspension, or loss, of its functional activity.
In patients with proliferative retinopathy, particularly if not treated with photocoagulation, severe hypoglycaemic episodes may result in transient amaurosis.
Differential localized changes in proliferative rates of populations of cells could play a crucial role in the patterning of the developing forebrain.
So far no case of " black adenoma " associated with a proliferative condition of the ipsilateral adrenal medulla has ben described.
It remains to be determined whether oxidants directly modulate the proliferative response.