Hansemann's "anaplasia " hypothesis seeks to find an explanation of the formation of new growths in the absence of the histological differentiation of the cell associated with a corresponding increase in its proliferative power and a suspension, or loss, of its functional activity.
acinussessment of pancreas slides from the earlier study confirmed the occurrence of proliferative lesions of the pancreatic acini.
In patients with proliferative retinopathy, particularly if not treated with photocoagulation, severe hypoglycaemic episodes may result in transient amaurosis.
AB - The process of terminal differentiation is associated with exit from the cell cycle and loss of the proliferative potential of cells.
CONCLUSION: Images show a decline in both cellular energetics and proliferative rate after successful chemotherapy.