Problems arose at the very outset.
An example of an outset is the start of a long hike.
He agreed and understood from the outset, so don't bother explaining again.
At the outset he owned the whole of it.
From the outset the prefect of Rome recognized the claims of Damasus, and exerted himself to support him.
This discontent was skilfully fanned by Mithradates the Great at the outset of his Roman campaigns.