Hoffmann (52) from essential syphilitic lesions, and now known as Treponeina (Spirochaete) pallida, Schaud.
An illness with no serious effects on humans, cowpox caused lesions on cows' udders which then could spread to dairymaids' hands.
In man, actually gross sensory defects follow even limited lesions of the cortex.
A widespread toxic action is indicated by the lesions found - cloudy swelling, which may be followed by fatty degeneration, in internal organs, capillary haemorrhages, &c. In septicaemia.
In another class of diseases, the organisms. first produce some well-marked local lesion, from which secondary extension takes place by the lymph or blood stream to other parts of the body, where corresponding lesions are formed.