Kiss-of-death definitions

Something that is ultimately ruinous, destructive, or fatal.
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An action or quality, often seemingly helpful, which is actually harmful or ruinous.
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A kiss on the cheek that signifies the death of the receiver, as delivered by a mob boss or one with such influence.
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(informal, idiomatic) Something that may seem good and favourable but that actually brings ruin to hopes, plans, etc.

The role in the soap opera was the kiss of death for Ann's career as a theatrical actress.

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Origin of kiss-of-death

From the kiss by which Judas betrayed Jesus (Mark 14:44–46)