Origin of In-silico
By analogy with Latin in vitro (“in glass"), used to refer to experiments in a test tube, using silicon to represent computing. At the time of the coining, computing was normally performed with silicon chips.
Latin in in pseudo-Latin silicō (from English silicon) (on the model of in vitro) (in vivo etc., in reference to the silicon chips in computers)
From American Heritage Dictionary of the English Language, 5th Edition
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