In Silico Definition

ĭn sĭlĭ-kō
By computer modeling.
A hypothesis that was tested in silico but not in vitro; in silico analysis.
American Heritage

Origin of In Silico

  • By analogy with Latin in vitro (“in glass"), used to refer to experiments in a test tube, using silicon to represent computing. At the time of the coining, computing was normally performed with silicon chips.

    From Wiktionary

  • Latin in in pseudo-Latin silicō (from English silicon) (on the model of in vitro) (in vivo etc., in reference to the silicon chips in computers)

    From American Heritage Dictionary of the English Language, 5th Edition

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