He graduated from Harvard in 1880 (in the class with Theodore Roosevelt), and the following year entered the banking house of Lee, Higginson & Co., in Boston.
He was a descendant of Francis Higginson (1588-1630), who emigrated from Leicestershire to the colony of Massachusetts Bay and was a minister of the church of Salem, Mass., in 1629-1630; and a grandson of Stephen Higginson (1743-1828), a Boston merchant, who was a member of the Continental Congress in 1783, took an active part in suppressing Shay's Rebellion, was the author of the "Laco" letters (1789), and rendered valuable services to the United States government as navy agent from the 11th of May to the 22nd of June 1798.
In politics Higginson was successively a Republican, an Independent and a Democrat.
Among musical organizations may be mentioned the Handel and Haydn Society (1815), the Harvard Musical Association (1837), the Philharmonic (1880) and the Symphony Orchestra, organized in 1881 by the generosity of Henry Lee Higginson.
Higginson, Horace Greeley and many more now and then contributed.