Sentence Examples

  • These individuals have had the unfortunate occurrence of a spontaneous mutation, meaning that in their early development, some random genetic accident affected their X chromosome, resulting in the defect that causes hemophilia A or B.
  • These include the coagulation disorders hemophilia A and hemophilia B, and von Willebrand's disease, a bleeding disorder caused by a deficiency in von Willebrand factor, an essential component of the coagulation system.
  • By 1997, approximately 800 different diagnostic tests were available, most of them for hereditary genetic disorders such as Tay-Sachs disease, sickle cell anemia, hemophilia, muscular dystrophy, and cystic fibrosis.
  • The most commonly known coagulation disorder is hemophilia, a condition in which a critical component of blood coagulation is missing, causing individuals to bleed for long periods of time before clotting occurs.
  • About 20 percent of all individuals with hemophilia A begin to produce antibodies in their blood against the specific factor protein; the presence of antibodies may then rapidly destroy infused factor VIII.