Game-over meaning

(video games) A message that appears on the screen of a computer or video game when all of the player's lives have been lost and the game must be started again from a checkpoint, the time runs out, or save point, or when the game has been successfully completed.
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(by extension) The end of some ongoing situation due to either failure or success.

If your wife finds out about us, it's game over!

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Origin of game-over

From game and over.