He suffered from infancy from great fragility of health, and nearly died in 1858 of gastric fever, which left much constitutional weakness behind it.
The death of Lowell's mother, and the fragility of his wife's health, led Lowell, with his wife, their daughter Mabel and their infant son Walter, to go to Europe in 1851, and they went direct to Italy.
These include severe skin fragility and sagging or aged-appearing skin.
In a condition known as purpura simplex, there is a tendency to bruise easily due to an increased fragility of the blood vessels.
Other factors must be considered when designing the ring, such as the fragility of each particular jewel and if the setting needs to protect the piece from chips and wear and tear.