An Rh-negative mother who was exposed to her fetus's Rh-positive blood during a previous pregnancy or delivery or who has accidentally received an Rh-positive blood transfusion has antibodies against Rh-positive blood cells.
They may experience problems if given a blood transfusion, and therefore they should wear a Medic Alert bracelet or have some other way of alerting any physician who treats them that they have this disorder.
Overall, however, transfusion and desferoxamine therapy have increased the life expectancy of individuals with the most severe types of beta thalassemia major to the fourth or fifth decade.
The risk of transfusion (such as transfusion reactions, potential toxins, and infections such as HIV or hepatitis) are carefully weighed against the severity of the anemia in the infant.
Medical science has not been able to create a synthetic alternative for blood, so when an individual requires a blood transfusion, doctors must have access to blood made available through blood donations.