The definition of a space shuttle is a reusasble, manned spacecraft that is designed to launch satellites and transport people and materials between Earth and a space station.
An example of space shuttle is the Space Shuttle Discovery that flew its last mission in 2011.
a manned, airplanelike spacecraft designed for shuttling back and forth, as between the earth and a space station, transporting personnel and equipment
A reusable spacecraft with wings for controlled descent in the atmosphere, designed to transport astronauts between Earth and an orbiting space station and also used to deploy and retrieve satellites.
space shuttle Discovery landing at Kennedy Space Center in Florida in March 2009
(plural Space Shuttles)