district in the lower west side of Manhattan: noted as a center for artists, art galleries, etc.
See Soho in American Heritage Dictionary 4
(sōˈhōˌ)
A district of central London, England. Inhabited in the 17th century mainly by immigrants, it is known today for its restaurants, theaters, and nightclubs.
also So·Ho A district of New York City on southwest Manhattan Island noted for its galleries, restaurants, and artists' lofts. The area is south of Houston Street, hence the name.