an inherited chronic anemia found chiefly among blacks, characterized by an abnormal red blood cell () containing a defective form of hemoglobin that causes the cell to become sickle-shaped when deprived of oxygen
See sickle cell anemia in American Heritage Dictionary 4
noun
A chronic, usually fatal anemia marked by sickle-shaped red blood cells, occurring almost exclusively in Black people of Africa or of African descent, and characterized by episodic pain in the joints, fever, leg ulcers, and jaundice. The disease occurs in individuals who are homozygous for a mutant hemoglobin gene. Also called sickle cell disease.