Origin of Santee; from uncertain or unknown; perhaps Amerindian tribal name river in E S.C., flowing southeast into the Atlantic: 143 mi (230 km)
- city in SW Calif., near San Diego: pop. 53,000
Origin of Santeeafter M. Santee, 1st postmaster
nounpl. Santee or San·tees
A member of the eastern branch of the Sioux, comprising the Mdewakanton, Sisseton-Wahpeton, and Wahpekute peoples, with present-day populations in Nebraska, Minnesota, the Dakotas, and Canada. Also called Dakota, Eastern Sioux, Santee Dakota, Santee Sioux.