Oy, or oy vay, is defined as a Yiddish expression used to describe frustration, worry, grief or other strong emotion.
When your husband forgets his keys for the 1,000,000th time and you have to bring them to him, this is an example of a time when you might say "oy."
used to express surprise, pain, grief, worry, etc.
Used especially to express irritation, dismay, sorrow, or self-pity.
Origin of oyYiddish
Yiddish אוי (oy, “oh, oy”)