They were not assailed by a great religious movement, but destroyed piecemeal by the revolt of tribes and districts.
This expedition was assailed by the Charruas and forced to return on foot, their leader himself being killed.
Admiral de Coligny made several unsuccessful endeavours to form a colony in Florida under Jean Ribault of Dieppe, Rene de Laudonniere and others, but the settlers were furiously assailed by the Spaniards and the attempt was abandoned.
Undeterred by the offence which these works gave to his ecclesiastical superiors, he published in 1858 the Einleitung in die Philosophie and Grundriss der Metaphysik, in which he assailed the doctrine of Thomas Aquinas, that philosophy was the handmaid of theology.
In 1509 the marshal Don Fernando Coutinho made an unsuccessful attack on the city; and in the following year it was again assailed by Albuquerque with 3000 troops.