We found that Wnt signaling modulates neuronal connectivity by regulating axon behavior, dendritic arborization and central synaptogenesis.
We are now using expression profiling in wildtype and Gli3 mutant mice to identify novel Wnt target genes in the developing cerebral cortex.
Wnt signaling regulates myogenic differentiation in the developing avian limb.
We are currently examining the effect of loss and gain of Wnt function in synaptic vesicle recycling using FM dyes.