His title of El Mansur, "The Victorious," was earned by the defeat he inflicted on Alphonso VIII.
His father prevailed on Innocent VIII.
He participated in the conclave which followed the death of Innocent VIII.
He made his home with his elder brother Piero at Florence throughout the agitation of Savonarola and the invasion of Charles VIII.
He obtained 150,000 ducats towards the expenses of the expedition from Henry VIII.