- An example of a two-fisted being is a human.
- An example of a two-fisted drinker is someone who drinks alcoholic drinks very quickly, as if using drinking two drinks at a time.
The definition of two-fisted is having or using both fists.
- Using or held by both hands: a two-fisted backhand stroke in tennis.
- Informal Characterized by vigor, roughness, or aggression: two-fisted frontier justice.