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Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen-induced anergy.
Figure 4. Synovial fluid CPPD crystals (compensated polarized light microscopy x400 ); scant numbers of rhomboid crystals showing weak positive birefringence.
My group has recently identified IL-6, which is produced by synovial fibroblasts, as a major anti-apoptotic factor in the rheumatoid joint.
Finally, we previously reported a role for A-SAA in matrix degradation through the production of metalloproteinases from RA synovial fibroblasts in vitro.
In this normal hand the small amounts of MCP joint synovial fluid can be seen.