He associated himself closely with his greater brother, the grand pensionary, and supported him throughout his career with great ability and vigour.
At the dissolution of the pensionary parliament, he was, in the new elections, returned for Bedfordshire.
The statesgeneral under the skilful management of the Grand Pensionary, John de Witt, retaliated by sending de Ruyter from the Mediterranean, where he was cruising against the Barbary pirates, to follow Holmes.
As he continued to preach the reformed doctrines in opposition to the royal ordinance, he was obliged to leave the country and retired to Holland, where he was well received and appointed one of the pensionary ministers of Gouda.
The pensionary conducted the legal business of the town, and was the secretary of the town council and its representative and spokesman at the meetings of the Provincial States.