Of course I'll go with you.
Of course I know that!
You will, of course, surrender all your future rights to the property.
Of course, there will be a few problems along the way.
Origin of of-course
- From literal meaning "of the ordinary course of events". Oldest attestation as "of course" from the 1540s, but previously used in the same sense as "by course" (then-spelled "bi cours", sic) since ca. 1300. (Source: Etymonline.com)