By the strain of anxiety and hard work his health and strength were seriously impaired, while the death of his wife was also a great shock to him; in the hope that rest in his native land might restore him, he left India, reaching England in April 1862.
One of the most remarkable of the Italian travellers was Ludovico di Varthema, who left his native land in 1502.
In that year a horde, variously estimated at from two to four thousand souls, with their flocks and their slaves, driven originally from their Central Asian homes by the pressure of Mongol invasion, and who had sought in vain a refuge with the Seljukian sultan Ala-ud-din Kaikobad of Konia, were returning under their chief Suleiman Shah to their native land.
The college to which Hofmann devoted nearly twenty of the best years of his life was starved; the coaltar industry, which was really brought into existence by his work and that of his pupils under his direction at that college, and which with a little intelligent forethought might have been retained in England, was allowed to slip into the hands of Germany, where it is now worth millions of pounds annually; and Hofmann himself was compelled to return to his native land to find due appreciation as one of the foremost chemists of his time.
In 1894 he escorted his father's remains to Hungary, and the following year resolved to settle in his native land and took the oath of allegiance.