Clinically it is to be observed that the drug is cumulative, being very slowly excreted, and that after it has been taken for some time the pulse may become irregular, the blood-pressure low, and the cardiac pulsations rapid and feeble.
Clinically, dysentery manifests itself with varying degrees of intensity, and it is often impossible without microscopical examination to determine between the amoebic and bacillary forms. In well-marked cases the following are the chief symptoms. The attack is commonly preceded by certain premonitory indications in the form of general illness, loss of appetite, and some amount of diarrhoea, which gradually increases in severity, and is accompanied with griping pains in the abdomen (tormina).
Next would come all the various syndromes, which are sets of clinically recognizable symptoms that occur together without a known cause.
In 1840, a German physician published a seventy-eight-page paper clinically describing polio.