tweak + -er; the drug-addict sense comes from the nickname of tweak for methamphetamines, in reference to addicts' punding behaviour.
"tweaker." YourDictionary, n.d. Web. 09 November 2018. <https://www.yourdictionary.com/tweaker>.
tweaker. (n.d.). Retrieved November 09th, 2018, from https://www.yourdictionary.com/tweaker
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