He was also associated with Antonio Perez as one of the secretaries who acted as the agents of the king in all dealings with the various governing boards which formed the Spanish administration.
Among them were Fra Raimondo, who became master-general of the Dominicans, William Flete, an ascetically-minded Englishman from Cambridge, Stefano Maconi, who joined the Carthusians and ultimately became prior-general, and the two secretaries, Neri di Landoccio and Francesco Malavolti.
Dissensions began from the first, and were peculiarly acute between Shelburne and Fox, the two secretaries of state.
On the 2nd of April he was constrained to submit to the formation of a new ministry, in which the duke of Portland was prime minister and Fox and North were secretaries of state.
Between that date and the Revolution there had been only two secretaries of state, whose duties were divided by a geographical division of the globe into northern and southern departments.