Sentence Examples


  • The transformation of piperidine into pyridine by W.
  • CONINE, or Coniine (a-propyl piperidine), C 5 H 17 N, an alkaloid occurring, associated with y-coniceine, conhydrine, pseudoconhydrine and methyl conine, in hemlock (Conium maculatum).
  • This substance when heated with hydriodic acid to 300° C. is converted into a-propyl piperidine, which can also be obtained by the reduction of a-allyl pyridine (formed from a-methyl pyridine and paraldehyde).
  • The a-propyl piperidine so obtained is the inactive (racemic) form of conine, and it can be resolved into the dextroand laevo-varieties by means of dextro-tartaric acid, the d-conine d-tartrate with caustic soda giving d-conine closely resembling the naturally occurring alkaloid.
  • The subject has been especially studied by Skraup, Konigs, and von Miller; Kiinigs and von Miller have proposed formulae consisting of a piperidine ring substituted with a vinyl group; in the former that is a bridge of CH 2 C(OH) from the nitrogen atom to the -y-carbon atom, connexion with the quinoline residue being made at the hydroxylic carbon atom through a CH2 group: whilst in the latter the piperidine ring is substituted by a methyl group in addition to the vinyl group and the bridge is simply C(OH), with which connexion is made as before.
 

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