kinase Definition
ki·nase (kī′nās′, kin′ās′)
noun
an enzyme capable of activating a zymogen or one causing the transfer of the terminal phosphate group, generally from ATP, to a receiving molecule
Etymology: kin(etic) + -ase
kinase Usage Examples
Converse of object
- activate: Using protein chips ( glass slides to which fragments of proteins are fixed ), the team showed which kinase activated which protein.
- encode: The gene family encoding protein kinases is the most commonly mutated in human cancer.
- inhibit: These have been shown to interact with and inhibit tyrosine kinases.
Adjective modifier
- cyclin-dependent: We have recently identified a number of putative regulatory genes, including cyclin-dependent kinases of Toxoplasma.
- mitogen-activated: Moreover, the activity of these transcription factors is regulated by mitogen-activated protein kinase ( MAPK ) pathways.
- polo-like: The motif is only observed in the Polo-like kinases.
- signal-regulated: PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation.
- p21-activated: Six members of the p21-activated kinase ( PAK ) family of protein kinases have been identified to date.
- wee1: C. McGowan ( Scripps Research Institute, U.S.A. ) for various constructs expressing human wee1 kinase.
Modifies a noun
- inhibitor: It is a type of drug called a tyrosine kinase inhibitor.
- cascade: This is probably the first evidence for a protein kinase cascade in higher plants.
- activation: Structural basis of cyclin dependent kinase activation by phosphorylation.
- substrate: The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.
- pathway: A role for the stress activated protein kinase pathway in the cellular response to DNA damage in fission yeast ( Prof.
Noun used with modifier
- tyrosine: Some of these proteins belong to a group called the tyrosine kinases.
- creatine: There is also a slightly elevated creatine kinase level in females carrying a DMD disease allele.
- phosphorylase: Phosphorylase kinase is a key enzyme in the control of glycogen metabolism.
- serine/threonine: Its amino acid sequence shows much greater homology to consensus sequences derived from protein serine/threonine kinases than to the consensus for protein tyrosine kinases.
- thymidine: The study product is an adenovirus derived vector which contains the gene for the enzyme thymidine kinase ( TK ).
- creatinine: No notable abnormalities in laboratory values associated with treatment were observed except for minor increases in serum concentrations of creatinine kinase.
Browse dictionary entries near kinase
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