In 1876, 1880 and 1884 he was a candidate for the presidential nomination, and in 1888 was nominated for vice-president on the ticket with Grover Cleveland, but was defeated in the election.
Beginning at the estuary of the Rio de la Plata, the boundary line ascends the Uruguay river, on the eastern side of the strategically important island of Martin Garcia, to the mouth of the Pequiry, thence under the award of President Grover Cleveland in 1894 up that small river to its source and in a direct line to the source of the Santo Antonio, a small tributary of the Iguassu, thence down the Santo Antonio and Iguassu to the upper Parana, which forms the southern boundary of Paraguay.
Having failed to secure a re-election to the Senate in '887, Harrison was nominated by the Republican party for the presidency in 1888, and defeated Grover Cleveland, the candidate of the Democratic party, receiving 233 electoral votes to Cleveland's 168.
Tilden, he lost the disputed election by the decision of the electoral commission, but he was elected with Grover Cleveland in 1884.
He was postmaster-general in President Grover Cleveland's cabinet from March 1885 until January 1888, and was then secretary of the interior until March 1889.
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