She died in 1828, leaving two sons, Daniel Fletcher, killed in the second battle of Bull Run, and Edward, a major in the United States army, who died while serving in the Mexican War, and a daughter Julia, who married Samuel Appleton.
Longfellow (who married Nathan Appleton's daughter) wrote his poem "The Old Clock on the Stairs."
Besides being a contributor to the magazines and encyclopedias on educational and philosophical subjects, he wrote An Introduction to the Study of Philosophy (1889); The Spiritual Sense of Dante's Divina Commedia (1889); Hegel's Logic (1890); and Psychologic Foundations of Education (1898); and edited Appleton's International Education Series and 'Webster's International Dictionary.
The critical weeklies of the past include the New York Literary Gazette (1834-1835, 1839), De Bow's Review (1846), the Literary World (1847-1853), the Criterion (1855-1856), the Round Table (1863-1864), the Citizen (1864-1873), and Appleton' s Journal (1869).
Appleton was one of the first cities in the United States to have an electric street railway line in operation; and electric street railways now traverse the entire Fox river valley as far as Fond du Lac on the south and Green Bay on the north.