SSRIs should not be used with any drug that increases serotonin concentrations, including MAO inhibitors, tramadol, sibutramine, meperidine, sumatriptan, lithium, St. John's wort, ginkgo biloba, and some anti-psychotic agents.
Some prescribed abortive medications include the triptan drugs such as sumatriptan (Imitrex), zolmitriptan (Zomig), naratriptan (Amerge), and ergotamine tartrate and caffeine (Caffergot).
For example, corticosteroids are very effective against pain caused by inflammation and swelling, and sumatriptan (Imitrex) was developed to treat migraine headaches.
Drugs that have been found to work well as abortive agents are ondansetron (Zofran, an antinausea drug) and sumatriptan (Imitrex, an antimigraine drug).
These drugs can be given intravenously, and sumatriptan is also available as a nasal solution.