The definition of out of the picture is someone or something who is no longer part of your life, who is no longer relevant or who is no longer a consideration.
An example of out of the picture is a guy you have broken up with and with whom you no longer stay in contact.
(idiomatic) Not included
in the matter being planned or under consideration; not a factor
in the present situation.
(idiomatic, euphemistic) Dead
(idiomatic) In a manner resulting in removal
from involvement in a situation.